Metabolic preconditions for the formation andprogression of steatohepatitis of alcoholic,mixed, non-alcoholic aetiology and their comorbidity withobesity and anaemic conditions

Background. The urgency of the problem comorbidity alcoholic steatohepatitis (ASH) and non-alcoholic (NASH) with anaemic conditions need for their differentiated correction is determined by significant frequency these diseases in world Ukraine presence syndrome mutual burden. Anaemia a marker progression to liver cirrhosis, which often manifestation hypersplenism increased destruction red blood cells spleen, as well frequent complications cirrhosis caused posthemorrhagic anaemia, occurs due bleedings from oesophageal gastric varices, portal hypertension decreased biosynthesis coagulation factors liver. purpose study was find out metabolic prerequisites formation alcoholic, mixed aetiology comorbid conditions. Materials methods. One hundred twenty-five patients were examined comorbidities lipid metabolism glycemic regulation disorders. Results. results investigations demonstrate hyperlipidemia (by 1.35–1.5 times) ASH, although conditions, content total cholesterol low-density lipoprotein (LDL) (p<0.05). Increased levels triglycerides (in range 1.6–2.2 high-density 1.45–1.55 all groups deepened In NASH there an increase LDL levels, rise atherogenic index 2.8 times Рatients obesity have high values glucose, insulin degree resistance 2.6 times, p<0.05), insulinemia are 2.9 3.0 respectively; p<0.05). ASH associated alcohol consumption, deficiency formed 1.4 1.2 develops addition (blood below lower 1.8 1.6 times). Conclusions. consequence pathology (hyperlipidemia, hyperglycemia, resistance), developed under hepatocyte steatosis